\ud83d\udca1The crystallization tank features a 316L stainless steel jacketed structure and supports both cooling crystallization and vacuum evaporation crystallization. Programmable temperature control allows for adjustment of crystal particle size, making it suitable for the crystallization, separation, and purification of active pharmaceutical ingredients, food additives, and fine chemical materials.<\/p>\n
Crystallization tanks are used to bring a solution to a supersaturated state through temperature changes or solvent evaporation, thereby causing crystals to precipitate. They are widely used in the crystallization and purification of active pharmaceutical ingredients, food additives, and fine chemical products.<\/p>\n
Add the hot saturated solution to the crystallization tank. Slowly cool it by passing cooling water (or refrigerant) through the jacket, or evaporate the solvent under vacuum to gradually increase the solution\u2019s supersaturation. The stirrer promotes uniform supercooling of the solution and controls the crystal growth rate and particle size distribution. Once crystallization is complete, the crystal slurry is discharged through the bottom valve and centrifuged to obtain wet crystals.<\/p>\n
\u2705 Stainless steel tank (with jacket\/half-pipe)<\/p>\n
316L stainless steel tank with a jacket or half-pipe heat exchange structure, ensuring uniform heat transfer and meeting the requirements of heating and cooling processes.<\/p>\n
\u2705 Agitators (paddle-type, turbine-type, propeller-type; variable-frequency speed control)<\/p>\n
A variety of impeller types are available, along with variable-frequency speed control for smooth speed regulation, ensuring uniform crystal growth.<\/p>\n
\u2705 Cooling\/Heating Systems (Chilled Water, Steam, Thermal Oil)<\/p>\n
Equipped with multiple heat sources to facilitate the entire process, from heating and dissolution to cooling and crystallization.<\/p>\n
\u2705 Vacuum system (for evaporation and crystallization)<\/p>\n
Evaporates solvents under negative pressure, enabling low-temperature evaporation and crystallization, and is suitable for heat-sensitive materials.<\/p>\n
\u2705 Sight Glasses and Lights<\/p>\n
Real-time monitoring of the crystallization status inside the tank facilitates production control.<\/p>\n
\u2705 Temperature, pH, and turbidity sensors<\/p>\n
Monitor various process parameters in real time online to ensure a stable crystallization environment.<\/p>\n
\u2705 CIP Cleaning Ball<\/p>\n
360\u00b0 spray cleaning ensures there are no blind spots inside the tank, meeting clean production requirements.<\/p>\n
\u2705 Precise Temperature Control: Zoned jacket design, programmable cooling curves, and stable supersaturation control.<\/p>\n
A multi-stage temperature control process ensures gradual heating and cooling, preventing the formation of fine, fragmented crystals caused by rapid cooling.<\/p>\n
\u2705 Controllable crystal morphology: Adjustable stirring speed and cooling rate to achieve the desired crystal morphology and particle size.<\/p>\n
Precise control of grain size is achieved through dual regulation of rotational speed and temperature change rate.<\/p>\n
\u2705 Smooth inner walls: Mirror-finish polishing with Ra \u2264 0.4 \u03bcm to prevent crystals from adhering to the walls.<\/p>\n
The highly polished inner wall of the tank reduces material adhesion, improves yield, and facilitates discharge.<\/p>\n
\u2705 Optional vacuum: Can be used for evaporation and crystallization without the need for a cooling medium.<\/p>\n
The vacuum evaporation process is suitable for materials that are not resistant to low temperatures, thereby expanding the range of applicable materials.<\/p>\n
\u2705 Easy to clean: No-dead-corner design, equipped with a CIP spray ball.<\/p>\n
The entire unit features a clean design and is equipped with an in-line cleaning system, in compliance with GMP standards.<\/p>\n
\u2705 Pharmaceuticals: Antibiotics (amoxicillin), vitamin C, and amino acid (glutamic acid) crystals.<\/p>\n
Cooling, crystallization, and purification in the active pharmaceutical ingredient (API) refinement process.<\/p>\n
\u2705 Ingredients: Glucose, xylitol, sorbitol, crystalline citric acid.<\/p>\n
Production of crystallized food additives.<\/p>\n
\u2705 Chemicals: sodium sulfate, potassium chloride, nitrates, crystalline oxalic acid.<\/p>\n
Precise crystallization and separation of inorganic salts.<\/p>\n
\u2705 New Materials: Lithium salts, crystal growth of catalysts.<\/p>\n
Crystallization and preparation of raw materials for new energy and fine catalysts.<\/p>\n
\u2705 Automatic Discharge Valve (Pneumatic or Electric)<\/p>\n
Automated, sealed discharge reduces manual contact.<\/p>\n
\u2705 Insulation (to reduce heat loss)<\/p>\n
Reduce heat and cold loss, and conserve energy in utility systems.<\/p>\n
\u2705 Vacuum Condensation Recovery System<\/p>\n
The evaporated solvent is condensed and recovered, and the solvent is recycled for reuse, which saves energy and protects the environment.<\/p>\n