\ud83d\udca1Biological fermentation tanks, also known as bioreactors, are made of 316L food-grade stainless steel. They support SIP (Sterilization-in-Place) aseptic sterilization, CIP (Cleaning-in-Place) automated cleaning, and high-precision PID parameter control, and are suitable for the fully automated aseptic production of microbial fermentation products, cell cultures, enzyme preparations, antibiotics, and probiotics.<\/p>\n
Biological fermentation tanks (bioreactors) are core aseptic reaction vessels used for the cultivation of microorganisms (bacteria, yeast, fungi) or animal and plant cells. They integrate a full suite of functions, including sterilization, aeration and agitation, temperature and humidity control, pH adjustment, dissolved oxygen control, automatic defoaming, and intelligent feed addition, and operate under aseptic, sealed conditions throughout the entire process. They are widely used in large-scale biological fermentation production across industries such as biopharmaceuticals, food fermentation, enzyme preparation, amino acid synthesis, probiotic cultivation, and biofuels.<\/p>\n
Pour the prepared culture medium into the fermenter, perform full sterilization using the built-in SIP steam system, and inoculate with microbial strains or animal and plant cells. The equipment precisely controls the temperature (25\u201345\u00b0C) via a jacket heat exchanger and built-in coils, and is equipped with a stirring system and a microporous gas distributor to enhance the transfer of oxygen from sterile air. The system automatically adjusts acidity and alkalinity to stabilize the pH and intelligently adds defoaming agents to prevent foam overflow. During the production process, carbon sources, nitrogen sources, and precursor materials are automatically replenished according to the metabolic requirements of the microbial strain. The entire process is intelligently controlled by a PLC. Upon completion of fermentation, discharge is performed under sealed conditions, ensuring a sterile, stable, and highly active fermentation environment throughout the entire process.<\/p>\n
\u2705 Stainless steel tank (SUS316L, electropolished inner surface)<\/p>\n
Pharmaceutical-grade 316L stainless steel with mirror-finish electropolished inner walls; no dead corners or residue; corrosion-resistant and easy to sanitize; meets aseptic production standards.<\/p>\n
\u2705 Agitation System (Mechanical Agitation \/ Magnetic Agitation + Variable-Frequency Motor)<\/p>\n
Variable-frequency speed-controlled stirring, with an optional seal-less magnetic stirring system to prevent bacterial contamination and accommodate the oxygenation requirements of different microbial strains.<\/p>\n
\u2705 Gas Distributor (Annular\/Microporous)<\/p>\n
It evenly disperses sterile air, significantly increasing the gas-liquid contact area and enhancing oxygen transfer efficiency.<\/p>\n
\u2705 Heat-exchange jacket\/built-in heat-exchange coil<\/p>\n
Rapid heating and cooling, precise maintenance of a constant temperature environment for fermentation, tailored to the metabolic requirements of specific microbial strains.<\/p>\n
\u2705 Online Smart Sensors<\/p>\n
Real-time monitoring of temperature, pH, dissolved oxygen (DO), foam, and CO\u2082 concentration, with accurate and traceable data.<\/p>\n
\u2705 Precision Peristaltic Pump Assembly<\/p>\n
Automatic replenishment of feedstock, addition of acid, addition of alkali, and addition of defoaming agent, with precise micro-dosing.<\/p>\n
\u2705 High-Efficiency Air Filtration System<\/p>\n
0.01 \u03bcm hydrophobic membrane filtration intercepts bacteria and particles in the air, ensuring a sterile air supply.<\/p>\n
\u2705 SIP Steam Sterilization System<\/p>\n
Fully automatic in-place sterilization; no need to disassemble the unit; the entire process is performed in a sterile, sealed environment.<\/p>\n
\u2705 CIP Automatic Cleaning Ball<\/p>\n
360\u00b0 spray cleaning with no blind spots, compliant with GMP cleanroom cleaning standards.<\/p>\n
\u2705 PLC Touchscreen Control System<\/p>\n
Visual operation interface with built-in historical graphs, data storage, and parameter logging, ensuring full traceability of production data.<\/p>\n
\u2705 High-level sterility assurance to prevent contamination<\/p>\n
Supports fully automated SIP (Sterilization-in-Place) with a fully sealed interface design. Combined with a sterile air filtration system, this eliminates microbial contamination at the source and ensures the yield of qualified fermentation products.<\/p>\n
\u2705 Intelligent control of high-precision parameters<\/p>\n
Using a PID intelligent algorithm, the system achieves a temperature control accuracy of \u00b10.1\u00b0C, a pH accuracy of \u00b10.02, and a dissolved oxygen (DO) accuracy of \u00b121 TP3T, precisely meeting the growth and metabolic needs of various bacterial strains.<\/p>\n
\u2705 Extremely high oxygen transfer efficiency, high fermentation yield<\/p>\n
With an optimized agitator design and a microporous aeration system, the oxygen transfer coefficient (KLa) can reach 200\u20131000 h\u207b\u00b9, resulting in high microbial activity and high fermentation yield.<\/p>\n
\u2705 Modular expansion, compatible with multiple processes<\/p>\n
It offers flexible expansion capabilities for exhaust gas analysis, metabolic monitoring, and external circulation systems, making it suitable for all scenarios\u2014from small-scale laboratory trials and pilot-scale testing to industrial-scale mass production.<\/p>\n
\u2705 GMP-compliant standardized design<\/p>\n
The materials used in the equipment are traceable, and a complete set of DQ\/IQ\/OQ\/PQ validation documents is available, ensuring full compliance with GMP production standards for biopharmaceuticals and food fermentation.<\/p>\n
\u2705 Antibiotic Fermentation<\/p>\n
Suitable for the microbial fermentation production of antimicrobial drugs such as penicillin, erythromycin, and cephalosporins.<\/p>\n
\u2705 Enzyme Preparation Production<\/p>\n
Used for the large-scale cultivation and production of industrial enzyme preparations such as proteases, amylases, and cellulases.<\/p>\n
\u2705 Amino Acid Fermentation<\/p>\n
Supports fermentation processes for food-grade and pharmaceutical-grade amino acids such as glutamic acid and lysine.<\/p>\n
\u2705 Probiotic Cultivation<\/p>\n
Suitable for the sterile cultivation and proliferation of beneficial microorganisms such as lactic acid bacteria, bifidobacteria, and yeast.<\/p>\n
\u2705 Vaccine Cell Culture<\/p>\n
Used for the aseptic culture of medical cells such as CHO cells and Vero cells.<\/p>\n
\u2705 Biofuel Fermentation<\/p>\n
Suitable for fermentation and concentration processes used in the production of biofuels such as ethanol and butanol.<\/p>\n
\u2705 Magnetic stirring (no mechanical seal)<\/p>\n
No sealing dead spots, zero risk of contamination, and suitable for high-purity, sterile production.<\/p>\n
\u2705 Automatic Online Sampling System<\/p>\n
Sealed, sterile sampling prevents contamination from manual sampling and ensures the authenticity of the samples.<\/p>\n
\u2705 Feed Tank for Fermentation<\/p>\n
Equipped with sterile feed storage, it enables continuous, precise feed production.<\/p>\n