CIP Cleaning System

CIP Online Cleaning System | Fully Automatic In-Place Cleaning Equipment for the Pharmaceutical and Food Industries

💡 The CIP (Clean-in-Place) system is a fully automatic, in-place cleaning device that requires no disassembly. It is controlled by a PLC program and uses a circulating spray of hot acid and alkali solutions for cleaning. Constructed from 316L food-grade stainless steel, it complies with GMP standards and is suitable for cleaning and disinfection on high-cleanliness production lines in the pharmaceutical, food, dairy, and biotechnology industries.

I. Product Introduction

A CIP (Clean-in-Place) system refers to an automated cleaning process that cleans the internal surfaces of equipment using circulating sprays of acid, alkali, hot water, and purified water, without the need to disassemble the equipment. It is widely used in industries that require high levels of cleanliness, such as pharmaceuticals, food, dairy, beverages, and biotechnology.

II. How It Works

Based on a preset program, the system sequentially delivers the cleaning solution (typically: pre-rinse → alkaline wash → intermediate rinse → acid wash → final rinse → purified water rinse) to the equipment to be cleaned via a cleaning pump, where it is evenly distributed over the inner walls by spray balls. The cleaning solution flows back into the cleaning tank for reuse (acid/alkali tanks). The final rinse water is discharged. The entire process is automatically controlled by a PLC, which regulates cleaning time, temperature, and concentration.

III. Main Structural Components

✅ Cleaning solution tanks (alkali tank, acid tank, hot water tank, purified water tank)

Store various cleaning media by category to enable the recovery and reuse of cleaning agents, thereby reducing consumable costs.

✅ Cleaning Pump (Variable-Frequency Drive)

Variable-frequency voltage-regulated water supply with adjustable flow rate and pressure, suitable for cleaning pipes and tanks of various sizes.

✅ Plate-type or shell-and-tube heat exchangers

Rapidly heats the cleaning medium to meet the requirements of high-temperature degreasing and descaling processes.

✅ Pneumatic Valves and Piping

Sanitary-grade piping is paired with automatic control valves to automatically switch between cleaning cycles, ensuring no dead spots and minimizing material buildup.

✅ Spray balls (fixed or rotating)

360° all-around spraying ensures there are no cleaning blind spots inside the tank.

✅ Conductivity meter, temperature sensor, liquid level switch

Real-time online monitoring of concentration, temperature, and liquid level ensures that cleaning parameters meet standards.

✅ PLC Touchscreen Control System

Visual programming allows you to start and stop the entire cleaning process with a single click.

✅ Dashcam (optional)

Automatically stores cleaning data and generates compliant cleaning records.

IV. Core Advantages

✅ Automation: One-click startup; the cleaning program runs automatically, reducing human error.

The entire process is automated via PLC, eliminating the need for manual equipment disassembly, assembly, or on-site supervision.

✅ Reusable: Acid and alkali tanks can be used multiple times, saving on cleaning agents.

Recovering, storing, and reusing acidic and alkaline chemicals reduces the costs of consumables and water.

✅ Verifiable: Records cleaning time, temperature, and conductivity, and provides a cleaning report.

Data is retained throughout the entire process to meet GMP audit and traceability requirements.

✅ Comprehensive coverage: Can be connected to tanks, pipes, valves, centrifuges, and heat exchangers.

It can be integrated with all equipment along the entire production line for one-stop online cleaning.

✅ GMP-compliant: Made of 316L stainless steel, with no dead corners, and suitable for SIP sterilization.

The media-contacting surfaces are made of 316L stainless steel with a mirror finish, suitable for sterile cleanrooms.

V. Typical Use Cases

✅ Pharmaceutical: Cleaning of solution preparation systems, fermenters, storage tanks, and filling lines.

Complete production lines for active pharmaceutical ingredients and traditional Chinese medicine extracts are designed for in-place cleaning.

✅ Dairy products: Cleaning of milk cans, pasteurizers, and homogenizers.

To meet the periodic cleaning requirements for dairy products in accordance with high hygiene standards.

✅ Beverages: Mixing tanks, filling machines, pipeline cleaning.

Removes sugar residue and flavoring residues, and prevents the growth of unwanted bacteria.

✅ Food: Cleaning of equipment used for condiments, sauces, and oils.

Effectively removes grease and sticky sauce residue.

✅ Biotechnology: Cleaning of fermenters, separation equipment, and chromatography columns.

Meets the cleanliness requirements for aseptic production in biopharmaceuticals.

VI. Key Technical Specifications

VII. Service Commitment

We offer end-to-end services ranging from equipment selection, solution design, and manufacturing to on-site installation and commissioning, as well as operations and maintenance training. All equipment can be customized to meet your needs, with nationwide delivery available. In Chongqing, we provide on-site service with a 24-hour response time.

🔗 Recommended Compatible Devices

Reference Guide for Selecting Production Line Equipment:
✅ Extraction of raw materials from the front end:Extraction equipment
✅ Material Storage and Allocation:Mixing and Storage Tanks
✅ Feedstock Refining:Separation and Purification Equipment