Crystallization Tank

Crystallization Tank | Evaporative Crystallization and Purification Equipment for the Pharmaceutical and Chemical Industries

💡The crystallization tank features a 316L stainless steel jacketed structure and supports both cooling crystallization and vacuum evaporation crystallization. Programmable temperature control allows for adjustment of crystal particle size, making it suitable for the crystallization, separation, and purification of active pharmaceutical ingredients, food additives, and fine chemical materials.

I. Product Introduction

Crystallization tanks are used to bring a solution to a supersaturated state through temperature changes or solvent evaporation, thereby causing crystals to precipitate. They are widely used in the crystallization and purification of active pharmaceutical ingredients, food additives, and fine chemical products.

II. How It Works

Add the hot saturated solution to the crystallization tank. Slowly cool it by passing cooling water (or refrigerant) through the jacket, or evaporate the solvent under vacuum to gradually increase the solution’s supersaturation. The stirrer promotes uniform supercooling of the solution and controls the crystal growth rate and particle size distribution. Once crystallization is complete, the crystal slurry is discharged through the bottom valve and centrifuged to obtain wet crystals.

III. Main Structural Components

✅ Stainless steel tank (with jacket/half-pipe)

316L stainless steel tank with a jacket or half-pipe heat exchange structure, ensuring uniform heat transfer and meeting the requirements of heating and cooling processes.

✅ Agitators (paddle-type, turbine-type, propeller-type; variable-frequency speed control)

A variety of impeller types are available, along with variable-frequency speed control for smooth speed regulation, ensuring uniform crystal growth.

✅ Cooling/Heating Systems (Chilled Water, Steam, Thermal Oil)

Equipped with multiple heat sources to facilitate the entire process, from heating and dissolution to cooling and crystallization.

✅ Vacuum system (for evaporation and crystallization)

Evaporates solvents under negative pressure, enabling low-temperature evaporation and crystallization, and is suitable for heat-sensitive materials.

✅ Sight Glasses and Lights

Real-time monitoring of the crystallization status inside the tank facilitates production control.

✅ Temperature, pH, and turbidity sensors

Monitor various process parameters in real time online to ensure a stable crystallization environment.

✅ CIP Cleaning Ball

360° spray cleaning ensures there are no blind spots inside the tank, meeting clean production requirements.

IV. Core Advantages

✅ Precise Temperature Control: Zoned jacket design, programmable cooling curves, and stable supersaturation control.

A multi-stage temperature control process ensures gradual heating and cooling, preventing the formation of fine, fragmented crystals caused by rapid cooling.

✅ Controllable crystal morphology: Adjustable stirring speed and cooling rate to achieve the desired crystal morphology and particle size.

Precise control of grain size is achieved through dual regulation of rotational speed and temperature change rate.

✅ Smooth inner walls: Mirror-finish polishing with Ra ≤ 0.4 μm to prevent crystals from adhering to the walls.

The highly polished inner wall of the tank reduces material adhesion, improves yield, and facilitates discharge.

✅ Optional vacuum: Can be used for evaporation and crystallization without the need for a cooling medium.

The vacuum evaporation process is suitable for materials that are not resistant to low temperatures, thereby expanding the range of applicable materials.

✅ Easy to clean: No-dead-corner design, equipped with a CIP spray ball.

The entire unit features a clean design and is equipped with an in-line cleaning system, in compliance with GMP standards.

V. Typical Use Cases

✅ Pharmaceuticals: Antibiotics (amoxicillin), vitamin C, and amino acid (glutamic acid) crystals.

Cooling, crystallization, and purification in the active pharmaceutical ingredient (API) refinement process.

✅ Ingredients: Glucose, xylitol, sorbitol, crystalline citric acid.

Production of crystallized food additives.

✅ Chemicals: sodium sulfate, potassium chloride, nitrates, crystalline oxalic acid.

Precise crystallization and separation of inorganic salts.

✅ New Materials: Lithium salts, crystal growth of catalysts.

Crystallization and preparation of raw materials for new energy and fine catalysts.

VI. Optional Configurations

✅ Automatic Discharge Valve (Pneumatic or Electric)

Automated, sealed discharge reduces manual contact.

✅ Insulation (to reduce heat loss)

Reduce heat and cold loss, and conserve energy in utility systems.

✅ Vacuum Condensation Recovery System

The evaporated solvent is condensed and recovered, and the solvent is recycled for reuse, which saves energy and protects the environment.

VII. Key Technical Specifications

VIII. Service Commitment

We offer end-to-end services ranging from equipment selection and process design to manufacturing, on-site installation and commissioning, and operator training. We provide custom solutions tailored to specific equipment capacities and operating conditions, with nationwide delivery available and 24-hour on-site after-sales service in Chongqing.

🔗 Recommended Compatible Devices

Selection of Equipment for a Crystallization Production Line:
✅ Solid-liquid separation of crystallization solution:Separation and Purification Equipment
✅ Solvent condensation recovery:Support Systems
✅ Storage and Preparation of Undiluted Solution:Mixing and Storage Tanks